No one has heard from Meg Murray's physicist father in more than a year — then Meg and her precocious brother, Charles Wallace, meet Mrs. Who, Mrs. Whatsit and Mrs. Which (the Mrs. Ws). The strange women tell the children that their father is in danger, and it's up to them (the kids) to travel through space and time to find him. Along with their new friend, Calvin, Meg and Charles Wallace learn about tessering or traveling into a fifth dimension through a "wrinkle" in time. Their father discovered how to tesser, which led to his imprisonment on the planet Camazotz by an evil disembodied brain known as IT. As they attempt to rescue Mr. Murray, Charles Wallace falls prey to IT's mind control. Meg, Calvin and Mr. Murray escape to the planet Ixchel where the Mrs. Ws and helpful, blind creatures (including Meg's caregiver, Aunt Beast) teach Meg what she must do to rescue her brother and return home.